Christophe Mulle is a cellular neurobiologist with expertise in electrophysiology of synaptic transmission and an international leader in studies on glutamate receptors, hippocampal synaptic circuits, and synaptopathies.
He characterized functional nicotinic receptors in the mammalian brain in the laboratory of Jean-Pierre Changeux and was further trained at the Salk Institute with Steve Heinemann. Since 1995, he has been guiding a CNRS laboratory which has pioneered the study of the role and trafficking of kainate receptors in synaptic function, in control conditions and in the context of temporal lobe epilepsy (TLE). He has greatly contributed to understanding the mechanisms of synaptic integration and plasticity in hippocampal circuits in the context of episodic memory encoding. His lab utilises an array of genetic and functional methods to interrogate the connectivity and function of local circuits in vivo in behavioural conditions.