Pipeline

Corlieve Therapeutic’s lead programme is based on the pioneering work of our Scientific Founders and their research for patients with drug resistant temporal lobe epilepsy (TLE).

In TLE, a phenomenon referred to as recurrent mossy fiber (rMF) sprouting occurs which, in association with ectopically expressed kainate receptors, has been linked with hippocampal hyperexcitability and seizure generation. Ectopic expression of kainate receptors therefore plays a major role in chronic seizures in this disease.

Targeting and suppressing aberrantly expressed kainate receptors in the hippocampus, using a gene therapy approach, constitutes a novel therapeutic option for TLE patients.

In TLE, a phenomenon referred to as recurrent mossy fiber (rMF) sprouting occurs which, in association with ectopically expressed kainate receptors, has been linked with hippocampal hyperexcitability and seizure generation. Ectopic expression of kainate receptors therefore plays a major role in chronic seizures in this disease.

Targeting and suppressing aberrantly expressed kainate receptors in the hippocampus, using a gene therapy approach, constitutes a novel therapeutic option for TLE patients.

  • Crépel V, Mulle C. Physiopathology of kainate receptors in epilepsy. Curr Opin Pharmacol. 2015 Feb;20:83-8.
  • Peret A, Christie LA, Ouedraogo DW, Gorlewicz A, Epsztein J, Mulle C, Crépel V. Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy. Cell Rep. 2014 Jul 24;8(2):347-54.
  • Crépel V, Mulle C. Physiopathology of kainate receptors in epilepsy. Curr Opin Pharmacol. 2015 Feb;20:83-8.
  • Peret A, Christie LA, Ouedraogo DW, Gorlewicz A, Epsztein J, Mulle C, Crépel V. Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy. Cell Rep. 2014 Jul 24;8(2):347-54.